David Sinclair,Ph.D. is a Senior Researcher at the National Health Institute in Helsinki, Finland. He has pioneered an approach to the treatment of alcoholism which has come to be called, the Sinclair Method. His protocol involves the use of opiate antagonists such as naltrexone or nalmefene to decrease the craving for alcohol over time. He finds that the use of these drugs just prior to alcohol consumption blocks endorphins and, thereby, leads to what he calls “pharmacological extinction,” which is to say the learned pleasure response to alcohol is unlearned.