#64 – The Sinclair Method for Treating Addiction

David Sinclair,Ph.D. is a Senior Researcher at the National Health Institute in Helsinki, Finland. He has pioneered an approach to the treatment of alcoholism which has come to be called, the Sinclair Method. His protocol involves the use of opiate antagonists such as naltrexone or nalmefene to decrease the craving for alcohol over time. He finds that the use of these drugs just prior to alcohol consumption blocks endorphins and, thereby, leads to what he calls “pharmacological extinction,” which is to say the learned pleasure response to alcohol is unlearned.



  1. Posted June 19, 2007 at 10:43 pm | Permalink

    Hi Dr. Dave,

    This is one of the best shows in the pile! Thanks for having Dr. Sinclair and allowing him to explain his therapy from A to Z


  2. Posted June 12, 2008 at 9:24 am | Permalink

    The article Cheers for moderation! details some examples of the effectiveness of The Sinclair Method.

  3. Roy Eskapa, PhD
    Posted October 8, 2008 at 6:56 pm | Permalink

    The first book on the Sinclair Method has just been published by BenBella Books, Dallas – 2008.

    The Cure for Alcoholism: Drink Your Way Sober Without Willpower, Abstinence, or Discomfort
    By Roy Eskapa with a Foreword by David Sinclair

  4. Kari
    Posted February 5, 2009 at 9:10 pm | Permalink

    Is there any place in Finland you can get this treatment ?

  5. Judy
    Posted August 19, 2009 at 4:50 pm | Permalink

    Two months taking Nal without any significant difference. Looked on the forums and many people are taking Nal in the AM.
    Could this be the way?

  6. Larry Killen
    Posted November 12, 2009 at 8:30 pm | Permalink

    As a successful candidate of the Sinclair Method, I find this Pod cast of great interest. I am a testament to his work.

  7. Olen
    Posted June 8, 2013 at 7:33 am | Permalink

    Hope for the addict :

  8. GPbaclofen
    Posted August 15, 2014 at 2:38 pm | Permalink

    i am from Germany, trained GP, and using baclofen for my own alcohol abuse, so far with good success for moderating my own alcohol consumption and reducing of cravings.
    Baclofen is probably one of the great pharmacological promises in the treatment of alcohol dep.endence/abuse in the future.
    So it seems with opiate antagonists when used properly as explained by Dr, Sinclair
    Nalmefene (one of the opiate antagonists mentionned along with Naloxone and Naltrexone) is planned to be launched on the European/German market in the next few months but its supposed pharmaceutical action should be much better explained by its proponents.
    Only after listening to Dr Sinclairs explanations I am convinced that it will work in a significant number of clients, may be even in conjunction with baclofen.

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